September 10 2003
Ananomouse Releases Mass Fatality Kinship Analysis Solution in Response to Need in the Wake of September 11 2001 Attacks
Addressing increasingly growing demands from medical and enforcement agencies, Ananomouse Corporation has announced the release of its debut product, a kinship analysis application named Bloodhound. Based on processes developed and implemented during the mass fatality investigations surrounding the Swissair Flight 111 air disaster of 1998 and the World Trade Centre attacks of September 11 2001, and successfully used as the first line of forensic DNA analysis during those investigations, Bloodhound is the only commercially available product capable of handling queries on this and even larger scale. While Ananomouse hopes that Bloodhound may never be needed for another mass fatality incident, the application is also designed to handle queries of missing-persons at a national level.
Bloodhound's release coincides with its presentation at the 20th International Congress International Society for Forensic Genetics, the leading gathering of international forensics scientists and professionals worldwide. The core strengths of the product are its high capacity of processing of queries against large data sets, application of independent two stage evaluation of evidence, and implementation of an intuitive user interface allowing ease of use by a variety of scientific and enforcement professionals in the field.
Bloodhound is an enterprise grade solution capable of condensing very large collections of complete/partial (STR) genotypes derived from remains to a restricted number of consensus genotypes believed to reflect the many different victims. Each consensus genotype is screened against the dataset of next-of-kin genotypes and personal effects for direct matches, evidence of genetic relatedness to kin through Kinship Indices, or successful production of a parentage trio with any two members of the next-of-kin cohort. Kinship Indices are calculated through a segregated score approach and by likelihood ratio calculations. A two-step algorithm that tests all possible parentage trio combinations for any given victim obtains matches of victims to parentage trios. A positive match to a parentage trio is then further cross-checked by the software against other kinship scoring results between the victim and other members of the same family to confirm that the purported family structure is consistent with Mendelian inheritance rules.
While current analyses are accessible to a limited number of forensic experts, Bloodhound's intuitive user interface enables DNA typing by a broader range of users in the forensic and law enforcement community, greatly accelerating the process of identification.